Award Information
Award #
2007-DN-BX-K146
Funding Category
Competitive
Location
Awardee County
East Baton Rouge
Congressional District
Status
Closed
Funding First Awarded
2007
Total funding (to date)
$580,337
Original Solicitation
Description of original award (Fiscal Year 2007, $580,337)
This project seeks to determine whether DNA evidence that has been deemed inadequate for PCR-based genotyping be restored to a usable condition if pre-treated with mixtures of DNA repair proteins. The efforts will focus on the application of cell extracts isolated from repair proficient organisms. In principle, extracts contain the full complement of DNA repair functions in the organism from which the extract was obtained. The work will take advantage of the range of DNA repair activities associated with Escherichia coli and Deinococcus radiodurans in development of reagents to assist in restoring damaged forensic evidence to a usable condition. Extracts will be modified by the engineering of strains to facilitate convenient removal of activities (such as nucleases) that could damage forensic samples and interfere with repair. Once suitable conditions are established, repair methodology focused on forensic markers will be explored.
ca/ncf
Date Created: August 27, 2007
Similar Awards
- Policing Leadership and Accountability: Harnessing Big Data and Causal Inference for Evaluating Police Reform Practices
- An Examination of the Law Enforcement Role in Implementing Extreme Risk Protection Orders
- Comprehensive Evaluation of Kinetic and Thermodynamic Approaches to Predict Evaporation of Ignitable Liquids for Fire Debris Applications