Calming Down: Could Sedative Drugs Be a Less-Lethal Option?
When law enforcement officers face a critical situation that puts innocent people at risk of injury or death, what options
do they have to diffuse the situation and save lives?
Russian Special Forces faced just such a situation in October 2002, when 50 Chechen terrorists stormed a Moscow theater and
held more than 800 civilians hostage with guns and explosives for nearly three days. Russian forces decided to use a gas to
subdue the terrorists, leading to the release of hundreds of hostages. Unfortunately, at least 129 hostages died during the
raid or in the following days. Some reports cited the effects of the gas — combined with the hostages' poor physical condition
and inadequate medical treatment following the rescue — as contributing to the victims' cause of death.
The siege of the Moscow theater raises questions for law enforcement in this country. Might calmative agents be a viable option
for officers to safely and effectively respond to critical situations?
In April 2007, the National Institute of Justice (NIJ) convened a panel to discuss pursuing research on whether calmative
agents — pharmaceuticals or sedative drugs that produce a calm or tranquil state — might be an addition or alternative to law enforcement's current less-lethal options. NIJ drew on experts from the scientific,
toxicological and bioethical communities; civil rights and advocacy organizations; and the legal and law enforcement communities
to form this community acceptance panel.
The panel reached general consensus that law enforcement officers need additional less-lethal options and that pursuing new
or updating existing research on the safety and viability of calmative agents was reasonable. Members agreed that further
research would provide a better understanding of the options, shortcomings and issues surrounding calmative agents. It is
important to note that the panel did not determine whether a tool could be developed, only that further research was an appropriate next step.
As a result of the panel's recommendations, NIJ funded research to explore the potential of operationalizing calmatives and
to examine possible pharmaceuticals, technologies and legal issues. The grant was given to Pennsylvania State University in
Limitations of Current Less-Lethal Devices
Every day, police officers across the country encounter people who pose a risk to the community and to themselves. It is paramount
that officers have effective options to safely deal with these situations.
The U.S. law enforcement community currently uses conducted-energy devices (CEDs) — also known as electro-muscular-disruption
devices or, more popularly, as stun guns — to subdue hostile, fleeing, belligerent or potentially dangerous suspects. CEDs
transmit pulsating electrical signals through small probes that attach to a suspect's clothing or body. The signals interfere
with communication between the brain and the muscular system, which results in temporary incapacitation. There is no conclusive
evidence to date that CEDs cause serious injury or death when used properly and within national guidelines, but in some situations
— such as a hostage situation — CEDs and other traditional less-lethal devices may not be suitable because they have a limited
In other situations, the use of less-lethal devices may raise concerns about the risk to police officers and suspects. For
example, people on drugs who show symptoms of a state known as "excited delirium" frequently experience a spike in body temperature,
increasing their risk of death. Concerns have been raised by law enforcement and the public about whether a shock from a CED
— introduced when a suspect's body temperature is rising due to drug-induced excited delirium — could contribute to sudden
Less-lethal techniques that involve the use of blunt force may also pose risks; blunt trauma to a person can cause organ damage
to the liver, kidneys, heart or brain, which could be permanent.
Could calmative agents serve as an alternative to CEDs or blunt force for law enforcement when a hostile situation arises
and officers are not in close proximity to the suspect — or when use of blunt force or a CED raises concerns about risks to
Research projects that examine the possibility of safely exposing someone to a pharmaceutical — even if it is for his or her
own protection — raise issues that must be addressed. For example:
- What pharmaceutical would be appropriate?
- What would be an appropriate dosage when a suspect's medical history is unknown?
- Is an antidote or reversal agent available?
- What method(s) of delivery would be reasonable or appropriate: ingestion, inhalation, absorption through the skin or injection?
- Does a medically trained professional need to deliver the drug or could a law enforcement officer be trained to do this?
Considering the Issues: Which Drug?
A 2001 study conducted at Penn State examined the advantages and limitations of using calmative agents as a possible less-lethal
option. According to the researchers, to be useful as a less-lethal option, a calmative agent ideally should:
- Have a fast onset.
- With a given dose, produce approximately the same magnitude of calm in people of similar body mass index and age range.
- Have a short or limited duration.
- Have reversible effects.
- Have no prolonged toxicity.
- Be easy to store and administer.
In the study, researchers examined several classes of drugs that may have utility as a calming agent, such as opiates, anti-psychotics,
neurolept anesthesia, ketamine, benzodiazepines, rohypnol (date rape drug), and non-benzodiazepines (Ambien). During a presentation to NIJ's community acceptance panel, one of the study's researchers highlighted the drug carfentanil
as meriting further investigation. Carfentanil, which is used to sedate large animals, is delivered intramuscularly, intravenously
and orally, and it has known antidotes, naloxone or narcan. However, because carfentanil is an opioid, it can have some undesirable
side effects, including respiratory depression, which can be fatal.
Additional drug options may be identified by looking to the pharmaceutical industry for already existing drugs or ones in
the research pipeline.
When Could Calmatives Be Used?
The circumstances in which a calmative agent could be used also must be thoroughly researched. Members of the NIJ community
acceptance panel emphasized that the goal of using any type of agent identified through extensive research would be to improve
the outcomes when using current less-lethal options. Different scenarios with different goals must be considered. For example,
the general consensus of the panel was that calmatives would not be recommended as a disbursement option for peaceful protests
or mass demonstrations. In these situations, they said, the potential risks would outweigh the intended goal.
In other circumstances — when a hostage situation becomes tactical, moving from verbal negotiations to force, for instance —
the hostage-taker is often killed in the ongoing mission to protect the lives of innocents. The panel agreed that, if a less-lethal
alternative became available that would spare the life of the hostage-taker as well, law enforcement would likely opt for
it. Medical personnel, armed with sufficient amounts of an antidote, could be on site to handle any medical issues that arose.
The ideal calmative, the panel noted, would put the hostage-taker to sleep or incapacitate him without harming nearby innocents.
Once the situation was under the control of law enforcement and the suspect was in custody, the suspect could then be aroused
in a safe environment, and proper medical treatment could be provided.
Several U.S. jurisdictions have medical protocols when dealing with suspects exhibiting signs of excited delirium. In Nashville,
Tenn., for example, officers may call upon their medically trained brethren to administer the drug Versed when appropriate.,
NIJ's community acceptance panel also emphasized that when researching the possibility of using chemical agents in a law enforcement
situation, some important legal considerations include the intended use of the agent, the appropriate dosage, the availability
of an antidote and the involvement of medical personnel. The panel also noted that a number of international treaties, conventions,
protocols or principles to which the U.S. is a party (such as the 1993 Chemical Weapons Convention, the 1907 Hague Convention,
the 1925 Geneva Gas Protocol, the 1972 Biological Weapons Convention and the 1986 Nairobi Convention) would have to be considered.
Moving Forward With Research
In some critical situations, CEDs and other current less-lethal devices might not be suitable options for officers. NIJ's
community acceptance panel focused its discussion on the very real need for alternative less-lethal tools and resources to
help ensure the ongoing safety and protection of law enforcement officers, suspects and the community at large. Although there
may or may not be a safe drug option available to help officers deal with critical situations safely and effectively, the
panel agreed that understanding the options, advantages and disadvantages surrounding chemical agents is important.
Research is the first step toward that understanding.
NIJ Journal No. 261, October 2008
About the Author
Danielle Weiss holds a Juris Doctor and Master of Forensic Sciences. An associate with Booz Allen Hamilton, she serves as a consultant and
technical advisor to the National Institute of Justice. She supports work on post-conviction DNA testing, forensic science
training development, solving cold cases with DNA, and the National Missing and Unidentified Persons System (NamUs). Weiss
has published a number of articles on the nexus of forensics and the law. Back to the top.
 "Russia Names Moscow Siege Gas" Exit Notice," BBC News, October 31, 2002; Miller, J., and E. Lichtblau, "U.S. Investigates Moscow Theater Siege, Seeking Qaeda Link," New York Times, November 19, 2003; McGeary, J., and P. Quinn-Judge, "Theater of War," Time Magazine, October 27, 2002; and "Gas Killed Moscow Hostages" Exit Notice, BBC News, October 27, 2002.
 Lakoski, J.M., W.B. Murray, and J.M. Kenny, The Advantages and Limitations of Calmatives for Use as a Non-Lethal Technique, University Park, Pa.: Pennsylvania State University, 2000: 7.
 For example, an independent study commissioned by NIJ recently found that the Taser X26 missed the target a significant amount
of times at 20 feet because of the probe’s spread angle. Mesloh, C., M. Henych, L.F. Thompson, and R. Wolf, A Qualitative & Quantitative Analysis of Conducted Energy Devices: TASER X26 vs. Stinger S200 (pdf, 117 pages), final report submitted to the National Institute of Justice, Washington, DC: May 2008 (NCJ 222769).
 Lakoski, The Advantages and Limitations, 11.
 Ibid., 9-10.
 Ibid., 15-16.
 The pharmaceutical industry looks to these drugs because the development of a new drug can be time-consuming and costly.
Approximately one out of every 10 pharmaceutical drugs in development proceeds to clinical trials. Once there, it can cost
more than $1 billion and take 8 to 10 years after chemical synthesis with no guarantee of approval by the FDA. Tufts Center
for the Study of Drug Development, Outlook 2008 Exit Notice, Boston: Tufts University, 2008.
 Metro Nashville Police Department, "Tasers to be Redeployed to Field Officers," press release, May 29, 2008; and Kalodimos,
D., "I-Team: Injection Used to Subdue Prisoners Exit Notice," WSMV Nashville, Tenn., July 13, 2008.
 In Miami-Dade County, in circumstances in which CEDs may need to be implemented but excited delirium is recognized, emergency
medical services are notified so they can respond to a scene with law enforcement. Once the suspect is successfully subdued
with the CED, medical personnel on site nasally administer Versed as part of medically necessary treatment. For more information
on Miami-Dade's protocol, see related story, "Medical Panel Issues Interim Findings on Stun Gun Safety."
Date Reviewed: June 20, 2011